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Papers of special significance were published in peer reviewed journals such as JBC, PNAS and Science, addressing the topics and sub-topics below during the referenced years:

FATTY ACID OXIDATION

  1. Reconstitution of the fatty acid oxidizing system (1953)
  2. Enzymes of beta-oxidation of fatty acids (1953, 1954, 1956)

FATTY ACID SYNTHESIS IN ANIMAL TISSUES

  1. Discovery of the de novo pathway of palmitate synthesis (1957)
  2. Bicarbonate requirement and identification of malonyl-CoA as an intermediate in fatty acid synthesis (1958)
  3. Discovery of the biotin enzyme, acetyl-CoA carboxylase (1958, 1960, 1962)
  4. Discovery of fatty acid synthase (1961, 1962)

FATTY ACID SYNTHESIS IN BACTERIA

  1. Acyl carrier protein (ACP) and its pantetheine prosthetic group (1964; 1965)
  2. Mechanism of fatty acid synthesis (1964)
  3. Isolation and identification of soluble enzymes (1966; 1968)

DESATURATION OF LONG-CHAIN FATTY ACIDS

  1. Requirement for lipids in the desaturation of stearyl-CoA by the stearyl-CoA desaturase (1969)
  2. Requirement for NADH-cytochrome b5 reductase in stearyl-CoA desaturase activity (1970)

MECHANISM OF ACTION OF EUKARYOTIC FATTY ACID SYNTHASE (FAS)

  1. Multifunctional nature of FAS (1975; 1976; 1978)
  2. Characterization of FAS mRNA (1980; 1981)
  3. Structural organization of FAS subunits (1980; 1981; 1982)
  4. Relationship of structure to function and mechanism of FAS (1983; 1984; 1985; 1987; 1988; 1990; 1991; 1993)
  5. Structure of genes coding for FAS protein (1983;1987;1988;1989)
  6. Regulation and expression of FAS proteins (1994; 1996; 1998; 2000)
  7. Cloning and expression of human fatty acid synthase (1996; 1997; 2001)
  8. FAS gene knockout in mice is embryonically lethal (2003)

ACETYL-CoA CARBOXYLASES 1 AND 2 (ACC1, ACC2)

  1. Physiologic significance of covalent and allosteric modification of ACC (1986; 1988)
  2. Hormonal regulation of acetyl-CoA carboxylases (1990)
  3. Structure of cDNA coding for acetyl-CoA carboxylases (ACC), identification of two isozymes ACC1 and ACC2 (1992; 1995; 1997)
  4. Subcellular localization of ACC1 and ACC2 (2000)
  5. Pharmaceutical manipulation of ACC2 may lead to loss of body fat in the context of normal caloric intake (2001)
  6. Knockout of ACC in S. cerevisiae arrests its cell cycle at G2/M (2003)
  7. ACC2 mutant mice are protected against obesity and type 2 diabetes (2003)
  8. ACC1 gene knockout in mice is embryonically lethal (2005)
  9. Inactivation of ACC1 causes growth retardation and reduced lipid accumulation in adipose tissues (2009)

METABOLIC SYNDROME

  1. Fatty acid metabolism as target of metabolic syndrome (2009)
  2. Fatostatin, a small organic molecule, blocks fat synthesis (2009)

BOOK - Comprehensive Overview

Wakil SJ, ed. (1970) Lipid Metabolism. New York: Academic Press.